Wellsville is a village in Columbiana County, Ohio, United States, along the Ohio River. The population was 4,133 at the 2000 census.
George Washington is reported to have surveyed the Wellsville area (just north of the Yellow Creek) in 1770 and noted in his journal that it was good bottom land. The Yellow Creek Massacre occurred near Wellsville in 1774. A group of Virginian settlers killed the relatives of a prominent Indian leader, Logan, who was camped on Yellow Creek. Logan took revenge, resulting in Lord Dunmore's War.
James Clark and William Wells first settled in the area in 1795. Although they had to leave for a while due to Indian attacks in the area, they returned between 1797 and 1800. Wellsville's first school and church were also established before 1800. A barn built in 1807 by the Aten family was moved to Hale Farm and Village in Bath, Ohio.