Tishomingo is a city in Johnston County, Oklahoma, United States. The population was 3,162 at the 2000 census. It is the county seat of Johnston County. It was the first capital of the Chickasaw Nation. Murray State College, a community college, with an annual enrollment of 1,600 students is located in Tishomingo. It is and has been the hometown to many Native Americans. It is also the location of KTSH, an automated radio station that once played classical music on 99.7Mhz on FM1.
Tishomingo is located at 34°14′8″N 96°40′39″W / 34.23556°N 96.6775°W / 34.23556; -96.6775 (34.235575, -96.677542).
According to the United States Census Bureau, the city has a total area of 4.8 square miles (12.3 km²), of which, 4.7 square miles (12.2 km²) of it is land and 0.04 square miles (0.1 km²) of it (0.63%) is water.