Adrian is a city in Malheur County, Oregon, United States, near the confluence of the Snake River and the Owyhee River. The population was 147 at the 2000 census and a census estimated population of 140 in 2009. It is part of the Ontario, OR–ID Micropolitan Statistical Area.
In 1913, Oregon Short Line Railroad built a branch into this part of Malheur County. There was a post office called Riverview on the east side of the Snake River and because the railroad did not want a station of the same name on the west side, the name Adrian was suggested by Reuben McCreary, who platted the townsite. The name was chosen to honor his birthplace, Adrian, Illinois. Riverview post office was established in 1911, but moved across the river in 1915 and the name changed to Adrian in 1919. It was previously thought that the city was named for James Adrian, a sheep rancher, but he did not arrive in the area until 1916.
Adrian is located on the Southern Alternate route of the Oregon Trail, a longer route that eliminated the need to cross the Snake River.