Mehama is an unincorporated community in Marion County, Oregon, United States, located on Oregon Route 22 and the North Santiam River. For statistical purposes, the United States Census Bureau has defined Mehama as a census-designated place (CDP). The census definition of the area may not precisely correspond to local understanding of the area with the same name. The population was 283 at the 2000 census. It is part of the Salem Metropolitan Statistical Area.
Mehama is the eastern terminus of Oregon Route 226, and is just one mile north of Lyons, across the North Santiam.
Mehama was named for the wife of pioneer James X. Smith. Smith laid out the townsite and operated a ferry on the North Santiam. A post office, misnamed Mehamah, was established in 1877, but the name was changed to Mehama by 1881.