Claysville is a borough in Washington County, Pennsylvania, United States. The population was 724 at the 2000 census. Claysville Elementary School, part of the McGuffey School District is located in Claysville. It is the birthplace of Benjamin Franklin Jones of the Jones and Laughlin Steel Company.
Claysville is located at 40°7′8″N 80°24′45″W / 40.11889°N 80.4125°W / 40.11889; -80.4125 (40.118984, -80.412536).
According to the United States Census Bureau, the borough has a total area of 0.3 square miles (0.8 km²), of which, 0.3 square miles (0.8 km²) of it is land and 3.12% is water.