Highspire is a borough in Dauphin County, Pennsylvania, United States. The population was 2,720 at the 2000 census. It is part of the Harrisburg–Carlisle Metropolitan Statistical Area.
The American actor Don Keefer was born in Highspire in 1916.
Highspire is located at 40°12′27″N 76°47′5″W / 40.2075°N 76.78472°W / 40.2075; -76.78472 (40.207622, -76.784698).