Manchester is a borough in York County, Pennsylvania, United States. The population was 2,350 at the 2000 census.
Settled in 1814, the village of Liverpool (now Manchester) was incorporated in 1864 in the eastern section of Manchester Township. During the Gettysburg Campaign of the American Civil War, Liverpool's merchants were raided by the 17th Virginia Cavalry.
Manchester is located at 40°03′39″N 76°43′11″W / 40.060943°N 76.719626°W / 40.060943; -76.719626.