Murrysville is a borough in Westmoreland County, Pennsylvania, United States. The population was 18,872 at the 2000 census. It became a home rule municipality in August 1976.
Murrysville is located at 40°26′5″N 79°39′24″W / 40.43472°N 79.65667°W / 40.43472; -79.65667 (40.434828, -79.656724). It is roughly 20 miles east of Pittsburgh, Pennsylvania on U.S. Route 22, just east of the county line that separates Westmoreland and Allegheny counties.
According to the United States Census Bureau, the borough had a total area of 36.9 square miles (95.7 km²), of which, 36.9 square miles (95.6 km²) of it is land and 0.03% is water.