Parkesburg is a borough in Chester County, Pennsylvania, United States. The population was 3,593 at the 2010 census. The Zip code is 19365.
Parkesburg was first known as the Fountain Inn, a tavern built ca. 1734. The inn ceased operation as a tavern around 1836 and became Parkesburg's first post office. In 1872, the Pennsylvania legislature authorized the formation of Parkesburg Borough (from Sadsbury Township). The town was named after noted politician John G. Parke. Today, the Fountain Inn is a private residence.
Parkesburg is located at 39°57′33″N 75°55′14″W / 39.95917°N 75.92056°W / 39.95917; -75.92056 (39.959066, -75.920447).