Wellsville is a borough in York County, Pennsylvania, United States. The population was 279 at the 2000 census.
Wellsville changed very little visually during the twentieth century; the borough's appearance remained that of a nineteenth-century community, complete with brick sidewalks and Gothic Revival and Greek Revival houses.:2 Because of its unusually high quality of preservation, nearly all of the community was placed on the National Register of Historic Places in 1977 as a historic district, the "Wellsville Historic District." Among the district's 48 contributing properties are an 1850s Methodist church, a small group of nineteenth-century commercial buildings, and the Wellsville House, an 1870s structure that has been used as a factory, museum, and restaurant.:9, 10
Wellsville is located at 40°3′1″N 76°56′26″W / 40.05028°N 76.94056°W / 40.05028; -76.94056 (40.050335, -76.940533).