Wyalusing is a borough in Bradford County, Pennsylvania, United States. The population was 564 at the 2000 census.
The history of Wyalusing dates back centuries and was originally known as M'chwihilusing. Before 1750 the settlement was known as Gahontoto and was home to the native American tribe the Tehotachsee. This small tribe would eventually be completely wiped out by the Cayuga tribe. In 1792 the chief of the Cayugas and about 20 other families rebuilt the town. In the 19th century is when the town really began to prosper with Wyalusing becoming a shipping area for logs and other items on the Susquehanna River. In 1820 the construction of the Welles Mill along the Wyalusing Creek made Wyalusing a prime area for people to farm and raise crops. In 1887 Wyalusing officially became a borough of Pennsylvania. Many of the buildings were built in the late 19th century and early 1920s still are part of Main Street today.
Wyalusing is also home to one of the biggest beef processing plants on the east coast. Cargill regional beef Wyalusing is located just a couple miles outside of town. This plant was originally started in the late 1970s by the local Taylor family as a small local meat processing plant. It eventually grew into a multi million dollar business that employs over 1200 people from the surrounding area. Cargill is one of the biggest suppliers of ground beef to large grocery chains such as Wegmans, Giant, Shop Rite and more. In 2005 the Taylor family sold the business to the Cargill corporation which is one of the largest privately owned companies in the United States.