Bethune is a town in Kershaw County, South Carolina, United States. The population was 352 at the 2000 census. It is part of the Columbia, South Carolina Metropolitan Statistical Area.
Bethune is located at 34°24′54″N 80°20′51″W / 34.415°N 80.3475°W / 34.415; -80.3475 (34.414881, -80.347414).
According to the United States Census Bureau, the town has a total area of 1.1 square miles (3.0 km²), all of it land.