Johnsonville is a city in Florence County, South Carolina, United States. The population was 1,418 at the 2000 census. It is part of the Florence Metropolitan Statistical Area.
Johnsonville is located at 33°49′4″N 79°26′54″W / 33.81778°N 79.44833°W / 33.81778; -79.44833 (33.817802, -79.448288).
According to the United States Census Bureau, the city has a total area of 1.6 square miles (4.1 km²), all of it land. This area was once the site of Thomas Sumter's hit and run action.