Pamplico is a town in southeastern Florence County, South Carolina, United States. The population was 1,139 at the 2000 census. It is part of the Florence Metropolitan Statistical Area.
Pamplico is located at 33°59′46″N 79°34′4″W / 33.99611°N 79.56778°W / 33.99611; -79.56778 (33.996071, -79.567777). It is located near the Pee Dee River, approximately 19 miles south of Florence. South Carolina Highway 51, a secondary thoroughfare for traffic to Myrtle Beach intersects the town.
According to the United States Census Bureau, the town has a total area of 1.9 square miles (4.8 km²), of which, 1.9 square miles (4.8 km²) of it is land and 0.54% is water.