Pendleton is a town in Anderson County, South Carolina, United States. The population was 2,966 at the 2000 census. It is a sister city of Stornoway in the Outer Hebrides of Scotland.
The Pendleton Historic District, consisting of the town and its immediate surroundings, was added to the National Register of Historical Places in 1970 as District No. 70000560. Particularly notable historic buildings on the Pendleton town square include Farmer's Hall and Hunter's Store. The latter is currently the headquarters of the Pendleton District Historical, Recreational and Tourism Commission. Near Pendleton are the historic plantation homes Ashtabula and Woodburn.
Notable schools include Pendleton Elementary, Mt Lebanon Elementary, LaFrance Elementary, Riverside Middle School, and Pendleton High School. Tri-County Technical College is located within the Town.