Chamberlain is a city in Brule County, South Dakota, United States. The population was 2,387 at the 2010 census. It is the county seat of Brule County. Chamberlain is home to the Akta Lakota Museum, which profiles the lives of nomadic Plains Indians. Chamberlain is also the home of the South Dakota Hall of Fame.
Chamberlain was named for Selah Chamberlain, a railroad director.
Chamberlain is located at 43°48′20″N 99°19′42″W / 43.80556°N 99.32833°W / 43.80556; -99.32833 (43.805548, -99.328444).