Colome is a city in Tripp County, South Dakota, United States. The population was 296 as of the 2010 census.
According to the United States Census Bureau, the city has a total area of 0.3 square miles (0.7 km²), all land.
As of the census of 2000, there were 340 people, 148 households, and 95 families residing in the city. The population density was 1,271.0 people per square mile (486.2/km²). There were 170 housing units at an average density of 635.5 per square mile (243.1/km²). The racial makeup of the city was 94.12% White, 2.06% Native American, 0.29% Asian, and 3.53% from two or more races. Hispanic or Latino of any race were 0.29% of the population.