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Dupree is a city in Ziebach County, South Dakota, United States. The population was 525 at the 2010 census. It is the county seat of Ziebach County.
Dupree is located at 45°3′0″N 101°36′4″W / 45.05°N 101.60111°W / 45.05; -101.60111 (45.050110, -101.601052).
According to the United States Census Bureau, the city has a total area of 0.4 square miles (1.0 km²), all of it land.