Highmore is a city in Hyde County, South Dakota, United States. The population was 795 at the 2010 census. It is the county seat of Hyde County.
Highmore is located at 44°31′7″N 99°26′28″W / 44.51861°N 99.44111°W / 44.51861; -99.44111 (44.518700, -99.441106).
According to the United States Census Bureau, the city has a total area of 1.9 square miles (4.9 km²), all of it land.