Leola is a city in McPherson County, South Dakota, United States. The population was 457 at the 2010 census. It is the county seat of McPherson County.
Leola is located at 45°43′16″N 98°56′19″W / 45.72111°N 98.93861°W / 45.72111; -98.93861 (45.721238, -98.938503).
According to the United States Census Bureau, the city has a total area of 0.7 square miles (1.8 km²), of which, 0.7 square miles (1.8 km²) of it is land and 1.41% is water.