Murdo is a city in Jones County, South Dakota, United States. The population was 488 at the 2010 census. It is the county seat of Jones County. Murdo is named for Murdo MacKenzie, a Texas cattleman, and was the hometown of current Republican U.S. Senator John Thune.
Murdo is located at 43°53′17″N 100°42′40″W / 43.88806°N 100.71111°W / 43.88806; -100.71111 (43.888173, -100.711109).
According to the United States Census Bureau, the city has a total area of 0.6 square miles (1.6 km²), all of it land.