Salem is a city in and the county seat of McCook County, South Dakota, United States. The population was 1,347 at the 2010 census. The current mayor is Kennth Scott, a long-time resident. Salem at one time was called Melas. This was to prevent confusion with the now non-existent community of Salena, South Dakota.
Salem is located at 43°43′34″N 97°23′12″W / 43.72611°N 97.38667°W / 43.72611; -97.38667 (43.725989, -97.386533).
According to the United States Census Bureau, the city has a total area of 1.0 square miles (2.6 km²), all of it land.