Greenville is the seat of Greenville County, in upstate South Carolina, United States. Greenville is the second largest city (by urban population) in the state of South Carolina. One of the principal cities of the Greenville-Mauldin-Easley Metropolitan Statistical Area (MSA), it had a municipal population of 58,409 and an urban population of 302,194 as of the 2010 census. The metropolitan area had an population of 636,986 in 2010 census..
Greenville is the largest city of the Greenville-Spartanburg-Anderson Combined Statistical Area (CSA) which in 2006 had an estimated population of 1,203,795, making it the largest MSA in the state of South Carolina. The CSA, an 8-county region of northwestern South Carolina, is known as "The Upstate". Greenville is located approximately halfway between Atlanta, Georgia and Charlotte, North Carolina along Interstate 85, and its metropolitan area also includes Interstates 185 and 385.
Greenville is located at 34°50′40″N 82°23′8″W / 34.84444°N 82.38556°W / 34.84444; -82.38556 (34.844313, -82.385428), roughly equidistant between Atlanta (120 miles southwest), and Charlotte, North Carolina.