Lugoff (pronounced Lew goff) is a census-designated place (CDP) in Kershaw County, South Carolina, United States. The population was 6,278 at the 2000 census. The population was nearly 85% rural in 2000. It is part of the Columbia, South Carolina Metropolitan Statistical Area.
Lugoff is located at 34°13′14″N 80°41′31″W / 34.22056°N 80.69194°W / 34.22056; -80.69194 (34.220455, -80.691826).
According to the United States Census Bureau, the CDP has a total area of 12.9 square miles (33.4 km²), of which, 12.8 square miles (33.3 km²) of it is land and 0.1 square miles (0.2 km²) of it (0.54%) is water.