Lewis Drug Stores

2701 S Minnesota Ave Ste 1
Sioux Falls SD 57105

Sponsored Topics

Opening Hours

  • Mon: 8am-9pm
  • Tue: 8am-9pm
  • Wed: 8am-9pm
  • Thu: 8am-9pm
  • Fri: 8am-9pm
  • Sat: 8am-9pm
  • Sun: 8am-9pm


  • Cash
  • Check
  • Discover
  • MasterCard
  • Visa

See a problem? Let us know!
Lewis Drug is a regional leader in working with families and hospitals to provide pharmaceuticals. The company has been locally owned for more than 60 years. Established in 1942, Lewis was the first self-service drug store in South Dakota and the surrounding region. In following years, Lewis further established itself with eight more stores, each offering a variety of general merchandise along with prescription and nonprescription drugs. Lewis is a market leader in pharmaceutical services. It is also a major retailer of electronics, clothing, garden and yard ware, office supplies, sporting goods, furniture, groceries and toys. Lewis Drug has locations in Sioux Falls, S.D.