Middleton is a city in Hardeman County, Tennessee, United States. The population was 602 at the 2000 census. The school's team name is the Middleton Tigers.
Middleton is located at 35°3′32″N 88°53′30″W / 35.05889°N 88.89167°W / 35.05889; -88.89167 (35.058798, -88.891728).
According to the United States Census Bureau, the city has a total area of 1.9 square miles (4.8 km²), of which, 1.8 square miles (4.8 km²) of it is land and 0.54% is water.