Adrian is a city in Oldham County, Texas, United States. The population was 159 at the 2000 census. A July 1, 2008 U.S. Census Bureau estimate placed the population at 149.
Adrian is located at 35°16′28″N 102°39′59″W / 35.27444°N 102.66639°W / 35.27444; -102.66639 (35.274489, -102.666385). It is situated along Interstate 40 (Old Route 66) in south central Oldham County, approximately 47 miles west of Amarillo. Adrian is the geo-mathematical midpoint of Route 66, positioned 1,139 miles from both Chicago, Illinois and Los Angeles, California.
According to the United States Census Bureau, the city has a total area of 0.9 square miles (2.3 km²), all of it land.