Pyote is a town in Ward County, Texas, United States. The population was 131 at the 2000 census.
Pyote began as a small town. Its fortunes rose with oil, but its population decreased when the railroad was built away from the town. At one time Pyote had 3,500 residents. The 1942 development of the Pyote Air Force Station and the 1967 development of what would become the West Texas State School raised the town's fortunes.
Pyote is located at 31°32′15″N 103°7′36″W / 31.5375°N 103.12667°W / 31.5375; -103.12667 (31.537478, -103.126771).