Tuscola is a city in Taylor County, Texas, United States. The population was 714 at the 2000 census. It is part of the Abilene, Texas Metropolitan Statistical Area.
Tuscola is located at 32°12′33″N 99°47′50″W / 32.20917°N 99.79722°W / 32.20917; -99.79722 (32.209060, -99.797126).
According to the United States Census Bureau, the city has a total area of 0.7 square miles (1.9 km²), all of it land.