Greenville is a census-designated place (CDP) in Augusta County, Virginia, United States. The population was 886 at the 2000 census. It is part of the Staunton–Waynesboro Micropolitan Statistical Area.
As early as 1794, Greenville was platted and divided into 14 lots of 1-acre (4,000 m2) and sold by Thomas and Jane Steele. Greenville soon became a very busy stagecoach stop. This was because there were 3 major roads all intersecting at or near Greenville. One road connected Greenville with Staunton, another ran from Waynesboro to Middlebrook, and the south road led to Midway (now Steeles Tavern), Fairfield, and Lexington. The town slowly grew, and by 1810, the population had grown to 162, comparing to Staunton's 1225, and Waynesboro's 250. An 1835 account of Greenville said that it had an extensive manufacturing flour mill and a woolen manufactory, two physicians in the area, contained 50 dwelling houses, 3 general stores, 2 taverns, 1 academy, 2 tanyards, 2 saddlers, 2 tailors, 1 blacksmith shop, 1 cabinet maker, 1 wheelwright, 1 saddle tree maker, 3 house carpenters, 1 hatter, and 4 boot and shoe makers. The population was about 250 in 1928.
Kate Smith, an immensely popular American radio singer of the Great Depression and World War II years, was born in Greenville. A statue of her stands outside the Wachovia Spectrum in Philadelphia because her rendition of "God Bless America" has long been considered a good luck charm for important games of the Philadelphia Flyers hockey team.