Keysville is a town in Charlotte County, Virginia, United States. The population was 817 at the 2000 census. One of two branches of Southside Virginia Community College is in Keysville. The surrounding area has tobacco and mixed farming.
Keysville is located at 37°2′24″N 78°29′1″W / 37.04°N 78.48361°W / 37.04; -78.48361 (37.039991, -78.483524).
According to the United States Census Bureau, the town has a total area of 1.2 square miles (3.1 km²), all of it land.