Nickelsville is a town in Scott County, Virginia, United States. The population was 383 at the 2010 census. It is part of the Kingsport–Bristol (TN)–Bristol (VA) Metropolitan Statistical Area, which is a component of the Johnson City–Kingsport–Bristol, TN-VA Combined Statistical Area – commonly known as the "Tri-Cities" region.
Nickelsville is located at 36°45′07″N 82°25′01″W / 36.751927°N 82.416951°W / 36.751927; -82.416951 (36.751927, -82.416951).
According to the United States Census Bureau, the town has a total area of 0.5 square miles (1.3 km2), all of it land.