Wytheville is a town in Wythe County, Virginia, United States. The population was 8,211 at the 2010 census. It is the county seat of Wythe County. The town is home to a Chautauqua Festival, held the third weekend in June every year since 1985. The Festival features live concerts, stage magic, arts and crafts, hot air ballooning, dance, children's activities and diverse carnival-style food. The Festival is held at Elizabeth Brown Memorial Park and is cosponsored by the county, town and the Wythe Arts Council. The town's name is pronounced "WITH-vill".
Wytheville is located at 36°56′52″N 81°5′13″W / 36.94778°N 81.08694°W / 36.94778; -81.08694 (36.947679, -81.086955).
According to the United States Census Bureau, the town has a total area of 14.3 square miles (37.0 km²), of which, 14.3 square miles (37.0 km²) of it is land and 0.04 square miles (0.1 km²) of it (0.14%) is water.