Pearisburg is a town in Giles County, Virginia, United States. The population was 2,729 at the 2000 census. It is the county seat of Giles County. Pearisburg is part of the Blacksburg–Christiansburg–Radford Metropolitan Statistical Area.
Pearisburg is located at 37°19′45″N 80°43′57″W / 37.32917°N 80.7325°W / 37.32917; -80.7325 (37.329184, -80.732490).
According to the United States Census Bureau, the town has a total area of 3.1 square miles (7.9 km²), all of it land.