Saltville is a town in Smyth and Washington counties in the U.S. state of Virginia. The population was 2,204 at the 2000 census. It is part of the Kingsport–Bristol (TN)–Bristol (VA) Metropolitan Statistical Area, which is a component of the Johnson City–Kingsport–Bristol, TN-VA Combined Statistical Area – commonly known as the "Tri-Cities" region.
Saltville was named for the salt marshes in the area. Prior to European settlement, these marshes attracted local wildlife. Excavations have recovered several well preserved skeletons of now extinct species dating back to the last ice age. Indigenous peoples of varying cultures hunted at the marshes. The historic Native American people in the area were the Chisca.
During the spring of 1567, Hernando Moyano led a combined force of natives and Spanish northward from Joara, a city in what is now western North Carolina. The force attacked and burned the Chisca village of Maniatique before they left. (The present-day Northwood High School in Saltville is located at the former village site.)