Palouse is a city in Whitman County, Washington, United States. The population was 998 at the 2010 census. Palouse is named for the region of farmland in which it is situated, and was incorporated in 1888.
Palouse was first settled in 1869 by William Ewing. The townsite was founded in 1875 by W.P. Breeding.
U.S. Census Bureau