Blair is a city in Trempealeau County, Wisconsin, along the Trempealeau River. The population was 1,273 at the 2000 census.
Blair is on the former Green Bay and Western Railroad, which ran down the Trempealeau River valley to Winona, Minnesota.
The city was first settled during the 1850s. The majority of the city's population are descended from Norwegian settlers, with a smaller group descended from German settlers. The city's Norwegian heritage is represented by annual lefse and lutefisk suppers at the churches and a love of polka music. A lefse company is located in Blair.