Brule is a town in Douglas County, Wisconsin, United States. The population was 591 at the 2000 census. The town takes its name from the nearby Bois Brule River, which flows north into Lake Superior. The census-designated place of Brule and unincorporated community of Winneboujou are located in the town of Brule.
U.S. Highway 2 and Wisconsin Highway 27 are two of the main arterial routes in the community.
Brule is located between the cities of Superior and Ashland on U.S. Highway 2.