Mullens is a city in Wyoming County, West Virginia. As of the 2000 census, it had a population of 1,769.
Located in a valley along the Guyandotte River within a mountainous region of southern West Virginia, the town was nearly destroyed by flash flooding in July 2001. While the town has attempted to redevelop with the aid of state and federal recovery money, many local businesses and residents have left the area permanently. Organizations like the Mullens-based Rural Appalachian Improvement League are working to improve conditions across the region. Mullens is also the hometown of New York Knicks coach Mike D'Antoni.
Mullens was incorporated as a town on September 17, 1912 and operated under a charter issued by the Circuit Court of Wyoming County. It was named for A. J. Mullins, who owned the land upon which the town is built. The towns original name was spelled with an "i" but when A.J didn't dot his "i" on a paper it looked as though he signed an "e". An Act of the West Virginia Legislature granting a charter to the City of Mullens was passed February 22, 1929.