Wellsburg is a city in and the county seat of Brooke County, West Virginia, United States. It is part of the Weirton–Steubenville, WV-OH Metropolitan Statistical Area. The 2000 Census recorded a population of 2,891, down from a count of 3,385 in the 1990 Census. The diverse economy includes one paper mill, a glass gift outlet, several telemarketing facilities, and a factory that does metal fabrication plus plastics molding.
The town was laid out in 1790, and its post office was opened on September 1, 1870.
In 1772, the Cox brothers, Friend, Israel, and Jonathan, made tomahawk rights claims totaling 1,200 acres in the area now including Wellsburg. In March 1788, Charles Prather purchased 481 acres from the Cox heirs for $3,000. In 1791, Prather petitioned Ohio County to incorporate the town of Charlestown, Virginia, naming it after himself. The original name continued until 1816, when it was changed to Wellsburg, to avoid confusion with Charles Town, Jefferson County. The new name was in honor of Alexander Wells, Charles Prather’s son-in-law, builder of the first large flour warehouse in the east. Late in 1890, nearby Midway and Lazearville were annexed to Wellsburg.