Midwest is a town in Natrona County, Wyoming, United States. It is part of the Casper, Wyoming Metropolitan Statistical Area. The population was 408 at the 2000 census.
Midwest is located at 43°24′30″N 106°16′41″W / 43.40833°N 106.27806°W / 43.40833; -106.27806 (43.408203, -106.278114).
According to the United States Census Bureau, the town has a total area of 0.4 square miles (1.1 km²), all of it land.