Upton is a town in Weston County, Wyoming, United States. The population was 872 at the 2000 census. The slogan for the town is "The best town on earth".
Upton is located at 44°6′12″N 104°37′33″W / 44.10333°N 104.62583°W / 44.10333; -104.62583 (44.103354, -104.625943).
According to the United States Census Bureau, the town has a total area of 1.3 square miles (3.4 km²), all of it land.