Buffalo is a city in Johnson County, Wyoming, United States. The population was 3,900 at the 2000 census. It is the county seat of Johnson County. In recent years, the town has boomed economically due to methane production from the coal bed methane extraction method used in the Powder River Basin and surrounding areas.
Buffalo is located at 44°20′51″N 106°42′4″W / 44.3475°N 106.70111°W / 44.3475; -106.70111 (44.347479, -106.701222).
According to the United States Census Bureau, the city has a total area of 3.5 square miles (9.1 km²), all of it land.