Independence is the county seat of Inyo County, California. Independence is located 41 miles (66 km) south-southeast of Bishop, at an elevation of 3930 feet (1198 m). The population was 669 at the 2010 census, up from 574 at the 2000 census.
The tiny village of Independence is bisected by U.S. Route 395, the main north-south highway through the Owens Valley.
Many travelers, especially international travelers, often tour the western United States on an itinerary which includes Las Vegas, Death Valley National Park, The Owens Valley, Mount Whitney and Yosemite National Park. U.S. 395 is an important part of this oft traveled route. Independence lies along U.S. 395 at the foot of the most spectacular part of the Sierra Nevada roughly half way between Death Valley and Yosemite.