Lewis is a city in Edwards County, Kansas, United States. The population was 486 at the 2000 census.
Lewis is located at 37°56′13″N 99°15′17″W / 37.93694°N 99.25472°W / 37.93694; -99.25472 (37.937014, -99.254728). According to the United States Census Bureau, the city has a total area of 0.3 square miles (0.8 km²), all of it land.
As of the census of 2000, there were 486 people, 183 households, and 133 families residing in the city. The population density was 1,523.1 people per square mile (586.4/km²). There were 226 housing units at an average density of 708.3 per square mile (272.7/km²). The racial makeup of the city was 75.72% White, 0.21% African American, 0.82% Native American, 21.19% from other races, and 2.06% from two or more races. Hispanic or Latino of any race were 34.16% of the population.