Clio is a city in Genesee County in the U.S. state of Michigan.
As of the 2000 census, the city had a population of 2,483. Clio is home to Michigan's second tallest construction, the WEYI Tower (also known as the Barrington Broadcasting's tower for WEYI and WBSF). The structure is an FM radio and television guyed radio mast, 1,323 feet (403.2m) tall. The city is considered a suburb of Flint and is located entirely within Vienna Township, but is administratively autonomous.
Originally named Varney after the city's first grain buyer, its name was changed in 1864 to Clio. The name change was brought on by Colonel Hill, a literary minded local hotel owner. Colonel Hill convinced the local ladies to name the town after the Greek goddess Clio, muse of history and poetry and daughter of Jupiter.