Manistique is a city in the Upper Peninsula of the U.S. state of Michigan. As of the 2000 census, the city population was 3,583. It is the county seat of Schoolcraft County and the only incorporated community in the county. The city lies on the north shore of Lake Michigan, at the southwest corner of Manistique Township, but is politically autonomous. Manistique was founded where the Manistique River flows into Lake Michigan, forming somewhat of a natural harbor, which has since been improved with breakwaters, dredging, and a lighthouse. The river also provides water for a paper mill, Manistique Papers, which forms a large portion of the local economy. The city's largest employer is Schoolcraft Memorial Hospital. The economy also depends heavily on tourism. The city is also the first setting of the musical The Christmas Schooner.
According to the United States Census Bureau, the city has a total area of 3.5 square miles (9.1 km²), of which, 3.2 square miles (8.3 km²) of it is land and 0.3 square miles (0.8 km²) of it (9.14%) is water.
As of the census of 2000, there were 3,583 people, 1,449 households, and 865 families residing in the city. The population density was 1,124.0 per square mile (433.7/km²). There were 1,611 housing units at an average density of 505.4 per square mile (195.0/km²). The racial makeup of the city was 87.02% White, 3.74% African American, 5.16% Native American, 0.73% Asian, 0.28% from other races, and 3.07% from two or more races. Hispanic or Latino of any race were 1.31% of the population.