Mesick is a village in Springville Township, Wexford County in the U.S. state of Michigan. The population was 447 at the 2000 census.
According to the United States Census Bureau, the village has a total area of 1.1 square miles (3.0 km²), all land.
As of the census of 2000, there were 447 people, 159 households, and 114 families residing in the village. The population density was 392.9 per square mile (151.4/km²). There were 185 housing units at an average density of 162.6 per square mile (62.7/km²). The racial makeup of the village was 98.66% White, 0.67% African American, 0.22% Native American, and 0.45% from two or more races. Hispanic or Latino of any race were 1.57% of the population.