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Bison is a town in and the county seat of Perkins County, South Dakota, United States. The population was 333 at the 2010 census.
Bison is located at 45°31′26″N 102°27′53″W / 45.52389°N 102.46472°W / 45.52389; -102.46472 (45.523911, -102.464634).
According to the United States Census Bureau, the town has a total area of 1.0 square miles (2.6 km²), all of it land.